USD 28–48 mn2025 estimate
PRESS RELEASE · 30 OCTOBER 2026
WS-23 Market Estimated at USD 50–100 mn in 2025, Says Market Krystal
MARKET KRYSTAL ESTIMATE
USD 50–100 mnWS-23 market, 2025- Confidence
- Grade C
- Forecast
- 2026–2035
- Scenarios
- to 2047
30 October 2026 – Market Krystal has published its WS-23 market report, covering demand, supply, the value chain and market size, with a forecast for 2026–2035 and scenarios to 2047.
WS-23 (2-isopropyl-N,2,3-trimethylbutyramide) is an odourless synthetic amide that triggers the TRPM8 cold receptor without the mint taste or harshness of menthol. It is used in chewing gum, confectionery, beverages and oral care, and has become the standard 'ice' cooling agent in e-liquids, disposable vapes and nicotine pouches. Supply is concentrated in a small group of Chinese specialty fine-chemical makers that sell to flavour houses and vape-liquid blenders, so vape regulation now shapes both demand and supplier risk.
Key findings
Demand
E-liquids and disposable vapes are the largest use of WS-23, with China's vape-manufacturing hub the largest consuming region.
Supply
Kunshan Asia Aroma, Anhui Chinaherb and Apple Flavor & Fragrance in China dominate output; Symrise markets Symcool WS-23 to flavour users.
Value chain
Nitrile intermediate (2-isopropyl-2,3-dimethylbutyronitrile) + Methylamine + Isopropyl and C3 alkylating reagents → WS-23 → E-liquids and disposable vapes, Chewing gum and confectionery, Oral care (toothpaste, mouthwash)
THE QUESTION THE REPORT ANSWERSHow large is WS-23 demand from vapes and nicotine products, who supplies it, and how exposed is it to tightening rules on synthetic coolants and disposable vapes?
Companies covered include
Kunshan Asia AromaAnhui Chinaherb Flavors & FragrancesApple Flavor & Fragrance GroupSymriseIFFGivaudanMars WrigleyBfR
Recent developments
Anhui Chinaherb reported 2025 cooling-agent revenue of RMB 161.2 mn, falling selling prices, and phase 2 of its 2,600 t/yr cooling-agent project in trial production since September 2025. Anhui Chinaherb
The UK banned the sale and supply of single-use vapes from 1 June 2025, a major outlet for WS-23-cooled 'ice' flavours. DEFRA (UK Government)
Germany's BfR (Opinion 010/2025) said e-liquids containing WS-23, WS-3 or WS-5 are not recommended toxicologically and noted government could ban coolants in e-cigarettes. BfR
THE FULL REPORT
WS-23 (vape and nicotine cooling agent) Market Report 2026-2035: Size, Producers, Pricing and Scenarios to 2047 (CAS 51115-67-4)
Producers and capacities, demand by application and region, value chain, pricing, market size and scenarios. PDF and Excel.
About Market Krystal
Market Krystal is a chemical market intelligence company. It publishes CAS-level market reports that follow each molecule from feedstock and production route through producers, applications and end users, and tracks chemical-industry developments from official company and regulator sources.