Market overview

n-Butyl cyanoacrylate (n-BCA, CAS 6606-65-1) is a medical adhesive used for skin closure (Histoacryl, Indermil, LiquiBand), endovascular embolisation of arteriovenous malformations and endoscopic treatment of gastric varices. It also has veterinary uses (Vetbond). It sets faster and more rigidly than 2-octyl cyanoacrylate.

The question this report answers
How much n-butyl cyanoacrylate do embolisation, endoscopy and skin closure use?

Market Krystal preliminary estimate (2025)
No public figure for the monomer. We estimate USD 15-50 mn. Confidence grade C: no reliable published figure; range built from the stated assumptions and narrowed in the full report.

Market dynamics
– Demand: skin closure, embolisation, varices, veterinary
– Supply: B. Braun, Medtronic, AMS, Chemence
– Price and margin: medical-grade premium
– Regulation and substitution: EU MDR

Key figures at a glance (third-party, cited)
– Cyanoacrylate surgical sealants and adhesives market: USD 1.52 bn (2025) to USD 2.62 bn by 2035 at 5.6% CAGR (Spherical Insights)
– Brands based on n-butyl cyanoacrylate include Histoacryl (B. Braun), Indermil, LiquiBand, PeriAcryl and Vetbond (Wikipedia)

Recent developments among key stakeholders
– No n-BCA-specific announcement was found for 2025-2026; Market Krystal tracks embolisation procedure growth and EU MDR re-certification

What this means for the market
Skin closure is shifting to 2-OCA in hospitals, but embolisation and endoscopy keep n-BCA demand growing. EU MDR raises barriers for smaller brands.

How published estimates compare
Published figures value finished devices. Market Krystal estimates n-BCA monomer volume by application (skin closure, embolisation, varices, veterinary).

Strategic scenarios to 2047
– Base: surgical and endovascular procedure volumes rise with ageing populations, keeping medical adhesive demand growing.
– Constrained supply: medical-grade monomer qualification under EU MDR and FDA limits suppliers; a single plant issue can disrupt supply.
– Technology transition: new sealants, biologic adhesives and device designs shift share among cyanoacrylate grades.
The swing factor for n-Butyl cyanoacrylate is embolisation and endoscopy growth. Signposts: procedure growth, EU MDR re-certifications, new device approvals.

What this report delivers
Annual volume (tonnes) and value (USD) for 2026-2035, segmented by application: skin closure, embolisation, gastric varices, dental and veterinary; product: pure n-BCA, n-BCA/2-OCA blends; region: Europe, North America, Asia-Pacific, Latin America. Each segment is backed by a producer capacity table, price benchmarks for 2020-2025 by grade and region, trade-flow analysis and a supplier risk map. Companies assessed include B. Braun, Medtronic, Advanced Medical Solutions, GluStitch, Chemence, 3M (Vetbond). The 2036-2047 outlook uses three explicit scenarios (base, constrained supply and technology transition) rather than a single extrapolated curve.

Who uses this report
Medical-device makers, monomer producers and healthcare investors.

Why our approach is evidence-based
Most CAS-level market listings publish a single number with no audit trail, and we regularly find figures that contradict their own growth rates or exceed the size of the market they sit inside. Market Krystal works the other way round. We start from physical evidence: plant capacities, production and trade data, company disclosures, regulatory texts and price records. We build volume and price separately and only then compute value. Every third-party figure is cited, every Market Krystal estimate is labelled with its method and a confidence grade, and conflicts between sources are shown rather than hidden. Confidence grades: A = two or more independent sources agree, or government or company data; B = one published estimate checked against volumes or prices; C = no reliable published figure, so the range is built from stated assumptions and narrowed in the full report.

Methodology and delivery
Prepared by the Market Krystal Chemicals Research Team. Each report is built around the buyer’s question: after purchase, a short scope confirmation fixes the priority regions, companies and applications, and the report is delivered within 5-7 business days with the Excel model behind every estimate, so buyers can audit and change the assumptions.

The purchased delivery includes the PDF report, Excel datasets and customization around the buyer’s priority region, company set, application or commercial question.

What this research answers

The study connects production routes, named suppliers, applications, regional demand, trade, pricing drivers and commercial opportunities for this CAS number. Detailed estimates and company analysis remain inside the purchased report.